Anti-Phospho-MOB1A-Thr12 antibody (STJ194726)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized phosho peptide around human MOB1 (Thr12)
General Information
| Short Description | Rabbit polyclonal anti-Phospho-MOB kinase activator 1A-Thr12 for use in WB, ELISA and IHC in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA/IHC |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Dilution Range | WB 1:500-2000IHC-P 1:50-300ELISA 2000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MOB1A |
| Gene ID | 55233 |
| Uniprot ID | MOB1A_HUMAN |
| Immunogen | Synthesized phosho peptide around human MOB1 (Thr12) |
| Specificity | This antibody detects endogenous levels of Human Mouse Rat MOB1 (phospho-Thr12) |
Additional Info
| Post Translational Modifications | Phosphorylated by STK3/MST2 and STK4/MST1 and this phosphorylation enhances its binding to LATS1. |
| Function | Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38. |
| Protein Name | Mob Kinase Activator 1aMob1 AlphaMob1aMob1 Homolog 1bMps One Binder Kinase Activator-Like 1b |
| Database Links | Reactome: R-HSA-2028269 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Mob Kinase Activator 1a antibodyAnti-Mob1 Alpha antibodyAnti-Mob1a antibodyAnti-Mob1 Homolog 1b antibodyAnti-Mps One Binder Kinase Activator-Like 1b antibodyAnti-MOB1A antibodyAnti-C2orf6 antibodyAnti-MOB4B antibodyAnti-MOBK1B antibodyAnti-MOBKL1B antibody |
Information sourced from Uniprot.org