| Host: | Rabbit |
| Applications: | WB/ELISA/IHC |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Phospho-Induced myeloid leukemia cell differentiation protein Mcl-1-Ser64 is suitable for use in Western Blot, ELISA and Immunohistochemistry research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 IHC-P 1:50-300 ELISA 2000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MCL1 |
| Gene ID: | 4170 |
| Uniprot ID: | MCL1_HUMAN |
| Specificity: | This antibody detects endogenous levels of Human Mcl-1 (phospho-Ser64) |
| Immunogen: | Synthesized phosho peptide around human Mcl-1 (Ser64) |
| Function | Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis. |
| Protein Name | Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 Bcl-2-Like Protein 3 Bcl2-L-3 Bcl-2-Related Protein Eat/Mcl1 Mcl1/Eat |
| Database Links | Reactome: R-HSA-6785807 Reactome: R-HSA-9725370 |
| Cellular Localisation | Membrane Single-Pass Membrane Protein Cytoplasm Mitochondrion Nucleus Nucleoplasm Cytoplasmic Associated With Mitochondria |
| Alternative Antibody Names | Anti-Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 antibody Anti-Bcl-2-Like Protein 3 antibody Anti-Bcl2-L-3 antibody Anti-Bcl-2-Related Protein Eat/Mcl1 antibody Anti-Mcl1/Eat antibody Anti-MCL1 antibody Anti-BCL2L3 antibody |
Information sourced from Uniprot.org