| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Phospho-Serine/threonine-protein kinase MAK-Tyr159 (126-175 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000 ELISA 1:40000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MAK |
| Gene ID: | 4117 |
| Uniprot ID: | MAK_HUMAN |
| Immunogen Region: | 126-175 aa |
| Specificity: | Phospho-MAK (Y159) Polyclonal Antibody detects endogenous levels of MAK protein only when phosphorylated at Y159. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human MAK around the phosphorylation site of Tyr159 at the amino acid range 126-175 |
| Post Translational Modifications | Autophosphorylated. Phosphorylated on serine and threonine residues. |
| Function | Essential for the regulation of ciliary length and required for the long-term survival of photoreceptors. Phosphorylates FZR1 in a cell cycle-dependent manner. Plays a role in the transcriptional coactivation of AR. Could play an important function in spermatogenesis. May play a role in chromosomal stability in prostate cancer cells. |
| Protein Name | Serine/Threonine-Protein Kinase Mak Male Germ Cell-Associated Kinase |
| Cellular Localisation | Nucleus Cytoplasm Cytoskeleton Microtubule Organizing Center Centrosome Spindle Midbody Cell Projection Cilium Photoreceptor Outer Segment Photoreceptor Inner Segment Localized In Both The Connecting Cilia And The Outer Segment Axonemes Localized Uniformly In Nuclei During Interphase To The Mitotic Spindle And Centrosomes During Metaphase And Anaphase And Also To Midbody At Anaphase Until Telophase |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Kinase Mak antibody Anti-Male Germ Cell-Associated Kinase antibody Anti-MAK antibody |
Information sourced from Uniprot.org