| Post Translational Modifications | Phosphorylated on Ser-311 and, to a higher extent, on Ser-406 by MARK3. Dephosphorylated on Ser-406 by PPP2CA. In resting cells, phosphorylated KSR1 is cytoplasmic and in stimulated cells, dephosphorylated KSR1 is membrane-associated. Phosphorylated by PKA at Ser-888. Phosphorylation at Ser-888 is required for cAMP-dependent activation of MAPK1 and/or MAPK3. |
| Function | Part of a multiprotein signaling complex which promotes phosphorylation of Raf family members and activation of downstream MAP kinases. Independently of its kinase activity, acts as MAP2K1/MEK1 and MAP2K2/MEK2-dependent allosteric activator of BRAF.upon binding to MAP2K1/MEK1 or MAP2K2/MEK2, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 and/or MAP2K2/MEK2. Promotes activation of MAPK1 and/or MAPK3, both in response to EGF and to cAMP. Its kinase activity is unsure. Some protein kinase activity has been detected in vitro, however the physiological relevance of this activity is unknown. |
| Protein Name | Kinase Suppressor Of Ras 1 |
| Database Links | Reactome: R-HSA-5673000Reactome: R-HSA-5674135Reactome: R-HSA-5675221Reactome: R-HSA-6802946Reactome: R-HSA-6802948Reactome: R-HSA-6802952Reactome: R-HSA-6802955Reactome: R-HSA-9649948Reactome: R-HSA-9656223 |
| Cellular Localisation | CytoplasmMembranePeripheral Membrane ProteinCell MembraneCell ProjectionRuffle MembraneEndoplasmic Reticulum MembraneIn Unstimulated CellsWhere The Phosphorylated Form Is Bound To A 14-3-3 ProteinSequestration In The Cytoplasm OccursFollowing Growth Factor TreatmentThe Protein Is Free For Membrane TranslocationAnd It Moves From The Cytoplasm To The Cell Periphery |
| Alternative Antibody Names | Anti-Kinase Suppressor Of Ras 1 antibodyAnti-KSR1 antibodyAnti-KSR antibody |
Information sourced from Uniprot.org
