| Host: | Rabbit |
| Applications: | WB/ICC |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-Phospho-Gamma-Catenin-Tyr-550 is suitable for use in Western Blot and Immunocytochemistry research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol |
| Purification: | Antigen Affinity Purified |
| Dilution Range: | WB 1:1000IHCICC 1:50IP |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | JUP |
| Gene ID: | 3728 |
| Uniprot ID: | PLAK_HUMAN |
| Specificity: | This antibody was cross-adsorbed to both phospho-tyrosine coupled to agarose and to dephosphorylated Gamma-Catenin (Tyr-550) peptide before affinity purification using phospho-Gamma-Catenin (Tyr-550) peptide (without carrier). The antibody detects an |
| Immunogen: | Phospho-Gamma-Catenin (Tyr-550) synthetic peptide (coupled to KLH) corresponding to amino acid residues around tyrosine 550 of human Gamma-Catenin. This peptide sequence is highly conserved in rat and mouse Gamma-Catenin. |
| Tissue Specificity | Expressed in the heart (at protein level). |
| Post Translational Modifications | May be phosphorylated by FER. |
| Function | Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton. |
| Protein Name | Junction PlakoglobinCatenin GammaDesmoplakin IiiDesmoplakin-3 |
| Database Links | Reactome: R-HSA-418990Reactome: R-HSA-5218920Reactome: R-HSA-6798695Reactome: R-HSA-6805567Reactome: R-HSA-6809371Reactome: R-HSA-8980692Reactome: R-HSA-9013026Reactome: R-HSA-9013106Reactome: R-HSA-9013148Reactome: R-HSA-9013406Reactome: R-HSA-9013407Reactome: R-HSA-9013409Reactome: R-HSA-9762292Reactome: R-HSA-9764302Reactome: R-HSA-9833576 |
| Cellular Localisation | Cell JunctionAdherens JunctionDesmosomeCytoplasmCytoskeletonMembranePeripheral Membrane ProteinCytoplasmic In A Soluble And Membrane-Associated Form |
| Alternative Antibody Names | Anti-Junction Plakoglobin antibodyAnti-Catenin Gamma antibodyAnti-Desmoplakin Iii antibodyAnti-Desmoplakin-3 antibodyAnti-JUP antibodyAnti-CTNNG antibodyAnti-DP3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance