Anti-Phospho-JAK1-Tyr1034/1035 antibody (STJ196339)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized phosho peptide around human Jak1 (Tyr1034 and 1035)
General Information
| Short Description | Rabbit polyclonal anti-Phospho-Tyrosine-protein kinase JAK1-Tyr1034/1035 for use in WB and IHC in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Dilution Range | WB 1:200-1000IHC-P 1:50-300 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | JAK1 |
| Gene ID | 3716 |
| Uniprot ID | JAK1_HUMAN |
| Immunogen | Synthesized phosho peptide around human Jak1 (Tyr1034 and 1035) |
| Specificity | This antibody detects endogenous levels of Human Mouse Rat Jak1 (phospho-Tyr1034 or 1035) |
Additional Info
| Post Translational Modifications | Autophosphorylated. Phosphorylated by TYK2 on tyrosine residues in response to type-I interferon signaling, leading to its activation. Phosphorylated on tyrosine residues in response to interferon gamma signaling. Dephosphorylation of Tyr-1034 and Tyr-1035 by PTPN2 negatively regulates cytokine-mediated signaling. Ubiquitinated by RNF125.leading to its degradation by the proteasome. |
| Function | Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor as well as interleukin (IL)-10 receptor. Kinase partner for the type I interferon receptor IFNAR2. In response to interferon-binding to IFNAR1-IFNAR2 heterodimer, phosphorylates and activates its binding partner IFNAR2, creating docking sites for STAT proteins. Directly phosphorylates STAT proteins but also activates STAT signaling through the transactivation of other JAK kinases associated with signaling receptors. |
| Protein Name | Tyrosine-Protein Kinase Jak1Janus Kinase 1Jak-1 |
| Database Links | Reactome: R-HSA-1059683Reactome: R-HSA-110056Reactome: R-HSA-112411Reactome: R-HSA-1169408Reactome: R-HSA-1266695Reactome: R-HSA-449836Reactome: R-HSA-5673001Reactome: R-HSA-6783783Reactome: R-HSA-6785807Reactome: R-HSA-6788467Reactome: R-HSA-877300Reactome: R-HSA-877312Reactome: R-HSA-8854691Reactome: R-HSA-8983432Reactome: R-HSA-8984722Reactome: R-HSA-8985947Reactome: R-HSA-9020558Reactome: R-HSA-9020591Reactome: R-HSA-9020956Reactome: R-HSA-9020958Reactome: R-HSA-909733Reactome: R-HSA-912526Reactome: R-HSA-912694Reactome: R-HSA-9674555Reactome: R-HSA-9679191Reactome: R-HSA-9705462Reactome: R-HSA-9705671Reactome: R-HSA-9732724Reactome: R-HSA-9833109 |
| Cellular Localisation | Endomembrane SystemPeripheral Membrane ProteinWholly IntracellularPossibly Membrane Associated |
| Alternative Antibody Names | Anti-Tyrosine-Protein Kinase Jak1 antibodyAnti-Janus Kinase 1 antibodyAnti-Jak-1 antibodyAnti-JAK1 antibodyAnti-JAK1A antibodyAnti-JAK1B antibody |
Information sourced from Uniprot.org