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Anti-Phospho-IRS1-Ser307 antibody (274-323 aa) (STJ90307)

Western blot analysis of lysates from K562 cells, using IRS-1 (Phospho-Ser307) Antibody. The lane on the right is blocked with the phospho peptide.
Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using IRS-1 (Phospho-Ser307) Antibody. The picture on the right is blocked with the phospho peptide.
Western blot analysis of VEC cells using Phospho-IRS-1 (S307) Polyclonal Antibody diluted at 1：1000
Immunofluorescence analysis of COS7 cells, using IRS-1 (Phospho-Ser307) Antibody. The picture on the right is blocked with the phospho peptide.
Western blot analysis of various cells using Phospho-IRS-1 (S307) Polyclonal Antibody diluted at 1：1000

Anti-Phospho-IRS1-Ser307 antibody (274-323 aa) (STJ90307)

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STJ90307

£46.00 - £226.00

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General Information
Product Properties
Target Information
Additional Info
Warranty Information

Host:	Rabbit
Applications:	WB/IHC/IF/ELISA
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Phospho-Insulin receptor substrate 1-Ser307 (274-323 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:500-1:2000 IHC 1:100-1:300 IF 1:200-1:1000 ELISA 1:10000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	IRS1
Gene ID:	3667
Uniprot ID:	IRS1_HUMAN
Immunogen Region:	274-323 aa
Specificity:	Phospho-IRS-1 (S307) Polyclonal Antibody detects endogenous levels of IRS-1 protein only when phosphorylated at S307.
Immunogen:	The antiserum was produced against synthesized peptide derived from the human IRS-1 around the phosphorylation site of Ser307 at the amino acid range 274-323

Function	May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit.
Protein Name	Insulin Receptor Substrate 1 Irs-1
Database Links	Reactome: R-HSA-109704 Reactome: R-HSA-112399 Reactome: R-HSA-112412 Reactome: R-HSA-1257604 Reactome: R-HSA-1266695 Reactome: R-HSA-198203 Reactome: R-HSA-201556 Reactome: R-HSA-2219530 Reactome: R-HSA-2428928 Reactome: R-HSA-2586552 Reactome: R-HSA-5673001 Reactome: R-HSA-6811558 Reactome: R-HSA-74713 Reactome: R-HSA-74749 Reactome: R-HSA-9603381 Reactome: R-HSA-9725370 Reactome: R-HSA-982772
Alternative Antibody Names	Anti-Insulin Receptor Substrate 1 antibody Anti-Irs-1 antibody Anti-IRS1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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