Anti-Phospho-HSPB6-Ser16 antibody (5-54 aa) (STJ91290)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human HSP20 around the phosphorylation site of Ser16 at the amino acid range 5-54
General Information
| Short Description | Rabbit polyclonal anti-Phospho-Heat shock protein beta-6-Ser16 (5-54 aa) for use in IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | IHC 1:100-1:300IF 1:200-1:1000ELISA 1:5000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | HSPB6 |
| Gene ID | 126393 |
| Uniprot ID | HSPB6_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human HSP20 around the phosphorylation site of Ser16 at the amino acid range 5-54 |
| Immunogen Region | 5-54 aa |
| Specificity | Phospho-HSP20 (S16) Polyclonal Antibody detects endogenous levels of HSP20 protein only when phosphorylated at S16. |
Additional Info
| Function | Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state. Seems to have versatile functions in various biological processes. Plays a role in regulating muscle function such as smooth muscle vasorelaxation and cardiac myocyte contractility. May regulate myocardial angiogenesis implicating KDR. Overexpression mediates cardioprotection and angiogenesis after induced damage. Stabilizes monomeric YWHAZ thereby supporting YWHAZ chaperone-like activity. |
| Protein Name | Heat Shock Protein Beta-6Hspb6Heat Shock 20 Kda-Like Protein P20Heat Shock Protein Family B Member 6 |
| Database Links | |
| Cellular Localisation | CytoplasmNucleusSecretedTranslocates To Nuclear Foci During Heat Shock |
| Alternative Antibody Names | Anti-Heat Shock Protein Beta-6 antibodyAnti-Hspb6 antibodyAnti-Heat Shock 20 Kda-Like Protein P20 antibodyAnti-Heat Shock Protein Family B Member 6 antibodyAnti-HSPB6 antibody |
Information sourced from Uniprot.org