Anti-Phospho-GRK2-Tyr86 antibody (STJ193211)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human GRK2 (Phospho-Tyr86)
General Information
| Short Description | Rabbit polyclonal anti-Phospho-Beta-adrenergic receptor kinase 1-Tyr86 for use in IHC, IF and WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IF/WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Dilution Range | IHC-P 1:50-200WB 1:500-2000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GRK2 |
| Gene ID | 156 |
| Uniprot ID | ARBK1_HUMAN |
| Immunogen | Synthesized peptide derived from the human GRK2 (Phospho-Tyr86) |
| Specificity | This antibody detects endogenous phospho levels of GRK2 (Phospho-Tyr86) at Human:Y86, Mouse:Y86, Rat:Y86 |
Additional Info
| Function | Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner. Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity. Inhibits relaxation of airway smooth muscle in response to blue light. |
| Protein Name | Beta-Adrenergic Receptor Kinase 1Beta-Ark-1G-Protein Coupled Receptor Kinase 2 |
| Database Links | Reactome: R-HSA-111933Reactome: R-HSA-416476Reactome: R-HSA-418555Reactome: R-HSA-5635838Reactome: R-HSA-8856825 |
| Cellular Localisation | CytoplasmCell MembranePostsynapsePresynapse |
| Alternative Antibody Names | Anti-Beta-Adrenergic Receptor Kinase 1 antibodyAnti-Beta-Ark-1 antibodyAnti-G-Protein Coupled Receptor Kinase 2 antibodyAnti-GRK2 antibodyAnti-ADRBK1 antibodyAnti-BARK antibodyAnti-BARK1 antibody |
Information sourced from Uniprot.org