Host: | Rabbit |
Applications: | WB |
Reactivity: | Mouse/Rat/Bovine/Canine/Human/Non-Human Primates |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-Phospho-NMDAR2C-Ser1096 is suitable for use in Western Blot research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | 100 µl in 10 mM HEPES (pH 7.5) , 150 mM NaCl, 100 µg per ml BSA and 50% Glycerol. |
Purification: | This antibody was antigen affinity purified from pooled serum. |
Dilution Range: | WB 1:1000 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | Grin2c |
Gene ID: | 24411 |
Uniprot ID: | NMDE3_RAT |
Immunogen: | Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser1096 conjugated to KLH. |
Tissue Specificity | Detected in cerebellum. |
Function | Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+). Participates in synaptic plasticity for learning and memory formation by contributing to the slow phase of excitatory postsynaptic current and long-term synaptic potentiation. Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). NMDARs mediate simultaneously the potasium efflux and the influx of calcium and sodium. Each GluN2 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators. |
Protein Name | Glutamate Receptor Ionotropic - Nmda 2c Glun2c Glutamate Nmda Receptor Subunit Epsilon-3 N-Methyl D-Aspartate Receptor Subtype 2c Nmdar2c Nr2c |
Database Links | Reactome: R-RNO-438066 Reactome: -RNO-8849932 Reactome: -RNO-9609736 |
Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein Postsynaptic Cell Membrane |
Alternative Antibody Names | Anti-Glutamate Receptor Ionotropic - Nmda 2c antibody Anti-Glun2c antibody Anti-Glutamate Nmda Receptor Subunit Epsilon-3 antibody Anti-N-Methyl D-Aspartate Receptor Subtype 2c antibody Anti-Nmdar2c antibody Anti-Nr2c antibody Anti-Grin2c antibody |
Information sourced from Uniprot.org