Anti-Phospho-GRIA2-Ser880 antibody (834-883 aa) (STJ91009)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human GluR2 around the phosphorylation site of Ser880 at the amino acid range 834-883
General Information
| Short Description | Rabbit polyclonal anti-Phospho-Glutamate receptor 2-Ser880 (834-883 aa) for use in WB, IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:20000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GRIA2 |
| Gene ID | 2891 |
| Uniprot ID | GRIA2_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human GluR2 around the phosphorylation site of Ser880 at the amino acid range 834-883 |
| Immunogen Region | 834-883 aa |
| Specificity | Phospho-GluR-2 (S880) Polyclonal Antibody detects endogenous levels of GluR-2 protein only when phosphorylated at S880. |
Additional Info
| Function | Ionotropic glutamate receptor that functions as a ligand-gated cation channel, gated by L-glutamate and glutamatergic agonists such as alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), quisqualic acid, and kainic acid. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system and plays an important role in fast excitatory synaptic transmission. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse upon entry of monovalent and divalent cations such as sodium and calcium. The receptor then desensitizes rapidly and enters in a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of L-glutamate. Through complex formation with NSG1, GRIP1 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting. |
| Protein Name | Glutamate Receptor 2Glur-2Ampa-Selective Glutamate Receptor 2Glur-BGlur-K2Glutamate Receptor Ionotropic - Ampa 2 |
| Database Links | Reactome: R-HSA-399710Reactome: R-HSA-416993Reactome: R-HSA-438066Reactome: R-HSA-9022699Reactome: R-HSA-9620244 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinPostsynaptic Cell MembranePostsynaptic Density MembraneInteraction With Cacng2Cnih2 And Cnih3 Promotes Cell Surface ExpressionDisplays A Somatodendritic Localization And Is Excluded From Axons In Neurons |
| Alternative Antibody Names | Anti-Glutamate Receptor 2 antibodyAnti-Glur-2 antibodyAnti-Ampa-Selective Glutamate Receptor 2 antibodyAnti-Glur-B antibodyAnti-Glur-K2 antibodyAnti-Glutamate Receptor Ionotropic - Ampa 2 antibodyAnti-GRIA2 antibodyAnti-GluA2 antibodyAnti-GLUR2 antibody |
Information sourced from Uniprot.org