Anti-Phospho-GAB2-Tyr643 antibody (609-658 aa) (STJ90977)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human Gab2 around the phosphorylation site of Tyr643 at the amino acid range 609-658
General Information
| Short Description | Rabbit polyclonal anti-Phospho-GRB2-associated-binding protein 2-Tyr643 (609-658 aa) for use in WB, IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:40000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GAB2 |
| Gene ID | 9846 |
| Uniprot ID | GAB2_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human Gab2 around the phosphorylation site of Tyr643 at the amino acid range 609-658 |
| Immunogen Region | 609-658 aa |
| Specificity | Phospho-Gab 2 (Y643) Polyclonal Antibody detects endogenous levels of Gab 2 protein only when phosphorylated at Y643. |
Additional Info
| Function | Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis. |
| Protein Name | Grb2-Associated-Binding Protein 2Grb2-Associated Binder 2Growth Factor Receptor Bound Protein 2-Associated Protein 2Pp100 |
| Database Links | Reactome: R-HSA-109704Reactome: R-HSA-1257604Reactome: R-HSA-1433557Reactome: R-HSA-1839117Reactome: R-HSA-2219530Reactome: R-HSA-2730905Reactome: R-HSA-6811558Reactome: R-HSA-8853659Reactome: R-HSA-8983432Reactome: R-HSA-912526Reactome: R-HSA-9607240Reactome: R-HSA-9645135Reactome: R-HSA-9674555Reactome: R-HSA-9680350Reactome: R-HSA-9702518Reactome: R-HSA-9703465Reactome: R-HSA-9703648 |
| Cellular Localisation | CytoplasmCell MembraneMembrane Raft |
| Alternative Antibody Names | Anti-Grb2-Associated-Binding Protein 2 antibodyAnti-Grb2-Associated Binder 2 antibodyAnti-Growth Factor Receptor Bound Protein 2-Associated Protein 2 antibodyAnti-Pp100 antibodyAnti-GAB2 antibodyAnti-KIAA0571 antibody |
Information sourced from Uniprot.org