Anti-Phospho-GAB2-Tyr452 antibody (STJ90630)

SKU:
STJ90630

Current Stock:
Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Phospho-GRB2-associated-binding protein 2-Tyr452 is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
ELISA 1:40000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: GAB2
Gene ID: 9846
Uniprot ID: GAB2_HUMAN
Specificity: Phospho-Gab 2 (Y452) Polyclonal Antibody detects endogenous levels of Gab 2 protein only when phosphorylated at Y452.
Immunogen: Synthesized phospho-peptide around the phosphorylation site of human Gab 2 (phospho Tyr452)
Function Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis.
Protein Name Grb2-Associated-Binding Protein 2
Grb2-Associated Binder 2
Growth Factor Receptor Bound Protein 2-Associated Protein 2
Pp100
Database Links Reactome: R-HSA-109704
Reactome: R-HSA-1257604
Reactome: R-HSA-1433557
Reactome: R-HSA-1839117
Reactome: R-HSA-2219530
Reactome: R-HSA-2730905
Reactome: R-HSA-6811558
Reactome: R-HSA-8853659
Reactome: R-HSA-8983432
Reactome: R-HSA-912526
Reactome: R-HSA-9607240
Reactome: R-HSA-9645135
Reactome: R-HSA-9674555
Reactome: R-HSA-9680350
Reactome: R-HSA-9702518
Reactome: R-HSA-9703465
Reactome: R-HSA-9703648
Cellular Localisation Cytoplasm
Cell Membrane
Membrane Raft
Alternative Antibody Names Anti-Grb2-Associated-Binding Protein 2 antibody
Anti-Grb2-Associated Binder 2 antibody
Anti-Growth Factor Receptor Bound Protein 2-Associated Protein 2 antibody
Anti-Pp100 antibody
Anti-GAB2 antibody
Anti-KIAA0571 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance