• Western blot analysis of lysates from HT29 cells treated with serum 20% 15', using GRB2 (Phospho-Ser159) Antibody. The lane on the right is blocked with the phospho peptide.
  • Immunohistochemistry analysis of paraffin-embedded human colon carcinoma, using GRB2 (Phospho-Ser159) Antibody. The picture on the right is blocked with the phospho peptide.

Anti-Phospho-GAB2-Ser159 antibody (125-174 aa) (STJ90967)

SKU:
STJ90967

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Phospho-GRB2-associated-binding protein 2-Ser159 (125-174 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:40000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: GAB2
Gene ID: 9846
Uniprot ID: GAB2_HUMAN
Immunogen Region: 125-174 aa
Specificity: Phospho-Gab 2 (S159) Polyclonal Antibody detects endogenous levels of Gab 2 protein only when phosphorylated at S159.
Immunogen: The antiserum was produced against synthesized peptide derived from the human GRB2 around the phosphorylation site of Ser159 at the amino acid range 125-174
Function Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis.
Protein Name Grb2-Associated-Binding Protein 2
Grb2-Associated Binder 2
Growth Factor Receptor Bound Protein 2-Associated Protein 2
Pp100
Database Links Reactome: R-HSA-109704
Reactome: R-HSA-1257604
Reactome: R-HSA-1433557
Reactome: R-HSA-1839117
Reactome: R-HSA-2219530
Reactome: R-HSA-2730905
Reactome: R-HSA-6811558
Reactome: R-HSA-8853659
Reactome: R-HSA-8983432
Reactome: R-HSA-912526
Reactome: R-HSA-9607240
Reactome: R-HSA-9645135
Reactome: R-HSA-9674555
Reactome: R-HSA-9680350
Reactome: R-HSA-9702518
Reactome: R-HSA-9703465
Reactome: R-HSA-9703648
Cellular Localisation Cytoplasm
Cell Membrane
Membrane Raft
Alternative Antibody Names Anti-Grb2-Associated-Binding Protein 2 antibody
Anti-Grb2-Associated Binder 2 antibody
Anti-Growth Factor Receptor Bound Protein 2-Associated Protein 2 antibody
Anti-Pp100 antibody
Anti-GAB2 antibody
Anti-KIAA0571 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance