Western blot analysis of lysates from K562 cells treated with PMA 125ng/ml 30', using CD32 (Phospho-Tyr292) Antibody. The lane on the right is blocked with the phospho peptide.

Anti-Phospho-FCGR2B-Tyr292 antibody (258-307 aa) (STJ90485)

SKU:
STJ90485
£48.00 - £252.00
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Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit polyclonal antibody anti-Phospho-Low affinity immunoglobulin gamma Fc region receptor II-b-Tyr292 (258-307 aa) is suitable for use in Western Blot and ELISA research applications.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
ELISA 1:10000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: FCGR2B
Gene ID: 2213
Uniprot ID: FCG2B_HUMAN
Immunogen Region: 258-307 aa
Specificity: Phospho-CD32 (Y292) Polyclonal Antibody detects endogenous levels of CD32 protein only when phosphorylated at Y292.
Immunogen: The antiserum was produced against synthesized peptide derived from the human CD32 around the phosphorylation site of Tyr292 at the amino acid range 258-307
Post Translational Modifications Phosphorylated by the SRC-type Tyr-kinases LYN and BLK.
Function Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis.
Protein Name Low Affinity Immunoglobulin Gamma Fc Region Receptor Ii-B
Igg Fc Receptor Ii-B
Cdw32
Fc-Gamma Rii-B
Fc-Gamma-Riib
Fcrii-B
Cd Antigen Cd32
Database Links Reactome: R-HSA-198933
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Antibody Names Anti-Low Affinity Immunoglobulin Gamma Fc Region Receptor Ii-B antibody
Anti-Igg Fc Receptor Ii-B antibody
Anti-Cdw32 antibody
Anti-Fc-Gamma Rii-B antibody
Anti-Fc-Gamma-Riib antibody
Anti-Fcrii-B antibody
Anti-Cd Antigen Cd32 antibody
Anti-FCGR2B antibody
Anti-CD32 antibody
Anti-FCG2 antibody
Anti-IGFR2 antibody

Information sourced from Uniprot.org

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