Anti-Phospho-FAM129B-Ser679/683 antibody (STJA0003632)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthetic phospho-peptide corresponding to amino acid residues surrounding Ser679/683 conjugated to KLH.
General Information
| Short Description | Rabbit polyclonal anti-Phospho-FAM129B-Ser679/683 for use in WB in Human, Mouse and Non-Human Primates samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Non-Human Primates |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | This antibody was antigen affinity purified from pooled serum. |
| Dilution Range | WB 1:1000 |
| Formulation | 100 µl in 10 mM HEPES (pH 7.5) , 150 mM NaCl, 100 µg per ml BSA and 50% Glycerol. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NIBAN2 |
| Gene ID | 64855 |
| Uniprot ID | NIBA2_HUMAN |
| Immunogen | Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser679/683 conjugated to KLH. |
Additional Info
| Post Translational Modifications | Phosphorylated at Ser-641, Ser-646, Ser-692 and Ser-696 by the BRAF/MKK/ERK signaling cascade. In melanoma cells, the C-terminal phosphorylation may prevent targeting to the plasma membrane. As apoptosis proceeds, degraded via an proteasome-independent pathway, probably by caspases. |
| Function | May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro. |
| Protein Name | Protein Niban 2Meg-3Melanoma Invasion By ErkMinervaNiban-Like Protein 1Protein Fam129b |
| Database Links | |
| Cellular Localisation | CytoplasmCytosolCell JunctionAdherens JunctionMembraneLipid-AnchorIn Exponentially Growing CellsExclusively CytoplasmicCell Membrane Localization Is Observed When Cells Reach Confluency And During TelophaseIn Melanoma CellsTargeting To The Plasma Membrane May Be Impaired By C-Terminal Phosphorylation |
| Alternative Antibody Names | Anti-Protein Niban 2 antibodyAnti-Meg-3 antibodyAnti-Melanoma Invasion By Erk antibodyAnti-Minerva antibodyAnti-Niban-Like Protein 1 antibodyAnti-Protein Fam129b antibodyAnti-NIBAN2 antibodyAnti-C9orf88 antibodyAnti-FAM129B antibody |
Information sourced from Uniprot.org