• Immunohistochemical analysis of paraffin-embedded human tonsil. 1, Antibody was diluted at 1:200 (4°C overnight). 2, Tris-EDTA, pH9.0 was used for antigen retrieval. 3, Secondary antibody was diluted at 1:200 (room temperature, 45min).

Anti-Phospho-ESR2-Ser87 antibody (53-102 aa) (STJ91236)

SKU:
STJ91236

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: IHC/IF/ELISA
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Phospho-Estrogen receptor beta-Ser87 (53-102 aa) is suitable for use in Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: IHC 1:100-1:300
ELISA 1:5000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ESR2
Gene ID: 2100
Uniprot ID: ESR2_HUMAN
Immunogen Region: 53-102 aa
Specificity: Phospho-ER Beta (S87) Polyclonal Antibody detects endogenous levels of ER Beta protein only when phosphorylated at S87.
Immunogen: The antiserum was produced against synthesized peptide derived from the human Estrogen Receptor-beta around the phosphorylation site of Ser87 at the amino acid range 53-102
Post Translational Modifications Phosphorylation at Ser-87 and Ser-105 recruits NCOA1.
Function Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform 2: Lacks ligand binding ability and has no or only very low ERE binding activity resulting in the loss of ligand-dependent transactivation ability.
Protein Name Estrogen Receptor Beta
Er-Beta
Nuclear Receptor Subfamily 3 Group A Member 2
Database Links Reactome: R-HSA-1257604
Reactome: R-HSA-2219530
Reactome: R-HSA-383280
Reactome: R-HSA-6811558
Reactome: R-HSA-8939211
Reactome: R-HSA-9009391
Cellular Localisation Nucleus
Alternative Antibody Names Anti-Estrogen Receptor Beta antibody
Anti-Er-Beta antibody
Anti-Nuclear Receptor Subfamily 3 Group A Member 2 antibody
Anti-ESR2 antibody
Anti-ESTRB antibody
Anti-NR3A2 antibody

Information sourced from Uniprot.org

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