• Immunohistochemistry analysis of paraffin-embedded human brain, using HER3 (Phospho-Tyr1222) Antibody. The picture on the right is blocked with the phospho peptide.
  • Western blot analysis of lysates from HUVEC cells treated with EGF 200ng/ml 30', using HER3 (Phospho-Tyr1222) Antibody. The lane on the right is blocked with the phospho peptide.
  • Immunofluorescence analysis of HUVEC cells, using HER3 (Phospho-Tyr1222) Antibody. The picture on the right is blocked with the phospho peptide.

Anti-Phospho-ERBB3-Tyr1222 antibody (1191-1240 aa) (STJ91083)

SKU:
STJ91083

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Phospho-Receptor tyrosine-protein kinase erbB-3-Tyr1222 (1191-1240 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ERBB3
Gene ID: 2065
Uniprot ID: ERBB3_HUMAN
Immunogen Region: 1191-1240 aa
Specificity: Phospho-ErbB-3 (Y1222) Polyclonal Antibody detects endogenous levels of ErbB-3 protein only when phosphorylated at Y1222.
Immunogen: The antiserum was produced against synthesized peptide derived from the human HER3 around the phosphorylation site of Tyr1222 at the amino acid range 1191-1240
Post Translational Modifications Autophosphorylated. Ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase.
Function Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it.ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. May also be activated by CSPG5. Involved in the regulation of myeloid cell differentiation.
Protein Name Receptor Tyrosine-Protein Kinase Erbb-3
Proto-Oncogene-Like Protein C-Erbb-3
Tyrosine Kinase-Type Cell Surface Receptor Her3
Database Links Reactome: R-HSA-1227986 P21860-1
Reactome: R-HSA-1236394 P21860-1
Reactome: R-HSA-1250196 P21860-1
Reactome: R-HSA-1257604 P21860-1
Reactome: R-HSA-1306955 P21860-1
Reactome: R-HSA-1358803 P21860-1
Reactome: R-HSA-1963642 P21860-1
Reactome: R-HSA-2219530 P21860-1
Reactome: R-HSA-5673001 P21860-1
Reactome: R-HSA-6785631 P21860-1
Reactome: R-HSA-6811558 P21860-1
Reactome: R-HSA-8847993 P21860-1
Reactome: R-HSA-8863795 P21860-1
Reactome: R-HSA-9664565 P21860-1
Reactome: R-HSA-9665686 P21860-1
Cellular Localisation Isoform 1: Cell Membrane
Single-Pass Type I Membrane Protein
Isoform 2: Secreted
Alternative Antibody Names Anti-Receptor Tyrosine-Protein Kinase Erbb-3 antibody
Anti-Proto-Oncogene-Like Protein C-Erbb-3 antibody
Anti-Tyrosine Kinase-Type Cell Surface Receptor Her3 antibody
Anti-ERBB3 antibody
Anti-HER3 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance