| Host: |
Rabbit |
| Applications: |
IHC/IF/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Phospho-Eukaryotic translation initiation factor 4 gamma 1-Ser1148 (1074-1123 aa) is suitable for use in Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000IHC 1:100-1:300ELISA 1:40000IF 1:50-200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
EIF4G1 |
| Gene ID: |
1981 |
| Uniprot ID: |
IF4G1_HUMAN |
| Immunogen Region: |
1074-1123 aa |
| Specificity: |
Phospho-eIF4G (S1148) Polyclonal Antibody detects endogenous levels of eIF4G protein only when phosphorylated at S1148. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the human eIF4G around the phosphorylation site of Ser1108 at the amino acid range 1074-1123 |
| Function | Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. Exists in two complexes, either with EIF1 or with EIF4E (mutually exclusive). Together with EIF1, is required for leaky scanning, in particular for avoiding cap-proximal start codon. Together with EIF4E, antagonizes the scanning promoted by EIF1-EIF4G1 and locates the start codon (through a TISU element) without scanning. As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation. |
| Protein Name | Eukaryotic Translation Initiation Factor 4 Gamma 1Eif-4-Gamma 1Eif-4g 1Eif-4g1P220 |
| Database Links | Reactome: R-HSA-1169408Reactome: R-HSA-156827Reactome: R-HSA-166208Reactome: R-HSA-429947Reactome: R-HSA-450408Reactome: R-HSA-72649Reactome: R-HSA-72662Reactome: R-HSA-72702Reactome: R-HSA-72706Reactome: R-HSA-9010553Reactome: R-HSA-975956Reactome: R-HSA-975957 |
| Cellular Localisation | CytoplasmNucleusStress Granule |
| Alternative Antibody Names | Anti-Eukaryotic Translation Initiation Factor 4 Gamma 1 antibodyAnti-Eif-4-Gamma 1 antibodyAnti-Eif-4g 1 antibodyAnti-Eif-4g1 antibodyAnti-P220 antibodyAnti-EIF4G1 antibodyAnti-EIF4F antibodyAnti-EIF4G antibodyAnti-EIF4GI antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
