Anti-Phospho-DOK1-Ser-450 antibody [WB, E] (STJA0005376)

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STJA0005376-100
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Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit polyclonal antibody anti-Phospho-Dok1-Ser-450 is suitable for use in Western Blot research applications.
Clonality : Polyclonal
Clone ID : WB, E
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol
Purification: Antigen Affinity Purified
Dilution Range: WB 1:1000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: DOK1
Gene ID: 1796
Uniprot ID: DOK1_HUMAN
Specificity: This antibody was cross-adsorbed to an unphosphorylated Dok1 (Ser-450) peptide before affinity purification using phospho-Dok1 (Ser-450) peptide. The purified antibody detects a band at 62 kDa* corresponding to Dok1 in western blots of human Jurkat c
Immunogen: Phospho-Dok1 (Ser-450) synthetic peptide (coupled to KLH) corresponds to amino acids surrounding serine 450 in human Dok1. This sequence is conserved in Dok1 from rat (Ser-449) and mouse (Ser-451). The site is not conserved in other Dok family member
Tissue Specificity Expressed in pancreas, heart, leukocyte and spleen. Expressed in both resting and activated peripheral blood T-cells. Expressed in breast cancer.
Post Translational Modifications Constitutively tyrosine-phosphorylated. Phosphorylated by TEC. Phosphorylated by LYN. Phosphorylated on tyrosine residues by the insulin receptor kinase. Results in the negative regulation of the insulin signaling pathway. Phosphorylated on tyrosine residues by SRMS.
Function DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3.
Protein Name Docking Protein 1
Downstream Of Tyrosine Kinase 1
P62(Dok
Pp62
Database Links Reactome: R-HSA-8849469
Reactome: R-HSA-8853659
Cellular Localisation Isoform 1: Cytoplasm
Nucleus
Isoform 3: Cytoplasm
Perinuclear Region
Alternative Antibody Names Anti-Docking Protein 1 antibody
Anti-Downstream Of Tyrosine Kinase 1 antibody
Anti-P62(Dok antibody
Anti-Pp62 antibody
Anti-DOK1 antibody

Information sourced from Uniprot.org

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