| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Phospho-Homeobox protein cut-like 1-Ser1215 is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CUX1 |
| Gene ID: | 1523 |
| Uniprot ID: | CUX1_HUMAN |
| Specificity: | This antibody detects endogenous levels of CUTL1 (Phospho-Ser1215) at Human, Mouse, Rat |
| Immunogen: | Synthesized peptide derived from human CUTL1 (Phospho-Ser1215) |
| Function | Transcription factor involved in the control of neuronal differentiation in the brain. Regulates dendrite development and branching, and dendritic spine formation in cortical layers II-III. Also involved in the control of synaptogenesis. In addition, it has probably a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor.binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer.may require the basic helix-loop-helix protein TCF4 as a coactivator. CDP/Cux p110: Plays a role in cell cycle progression, in particular at the G1/S transition. As cells progress into S phase, a fraction of CUX1 molecules is proteolytically processed into N-terminally truncated proteins of 110 kDa. While CUX1 only transiently binds to DNA and carries the CCAAT-displacement activity, CDP/Cux p110 makes a stable interaction with DNA and stimulates expression of genes such as POLA1. |
| Protein Name | Homeobox Protein Cut-Like 1 Ccaat Displacement Protein Cdp Cdp/Cux P200 Homeobox Protein Cux-1 Cleaved Into - Cdp/Cux P110 |
| Database Links | Reactome: R-HSA-6811438 Reactome: R-HSA-1839117 Reactome: R-HSA-5655302 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Homeobox Protein Cut-Like 1 antibody Anti-Ccaat Displacement Protein antibody Anti-Cdp antibody Anti-Cdp/Cux P200 antibody Anti-Homeobox Protein Cux-1 Cleaved Into - Cdp/Cux P110 antibody Anti-CUX1 antibody Anti-CUTL1 antibody |
Information sourced from Uniprot.org