Anti-Phospho-CNOT2-Ser101 antibody (67-116 aa) (STJ91265)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human CNOT2 around the phosphorylation site of Ser101 at the amino acid range 67-116
General Information
| Short Description | Rabbit polyclonal anti-Phospho-CCR4-NOT transcription complex subunit 2-Ser101 (67-116 aa) for use in IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | IHC 1:100-1:300ELISA 1:10000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CNOT2 |
| Gene ID | 4848 |
| Uniprot ID | CNOT2_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human CNOT2 around the phosphorylation site of Ser101 at the amino acid range 67-116 |
| Immunogen Region | 67-116 aa |
| Specificity | Phospho-CNOT2 (S101) Polyclonal Antibody detects endogenous levels of CNOT2 protein only when phosphorylated at S101. |
Additional Info
| Function | Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation.the repressive function may specifically involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of embryonic stem (ES) cell identity. |
| Protein Name | Ccr4-Not Transcription Complex Subunit 2Ccr4-Associated Factor 2 |
| Database Links | Reactome: R-HSA-429947Reactome: R-HSA-6804115Reactome: R-HSA-9820841 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Ccr4-Not Transcription Complex Subunit 2 antibodyAnti-Ccr4-Associated Factor 2 antibodyAnti-CNOT2 antibodyAnti-CDC36 antibodyAnti-NOT2 antibodyAnti-HSPC131 antibodyAnti-MSTP046 antibody |
Information sourced from Uniprot.org