| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Phospho-CUB domain-containing protein 1-Tyr743 is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:1000-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CDCP1 |
| Gene ID: | 64866 |
| Uniprot ID: | CDCP1_HUMAN |
| Specificity: | This antibody detects endogenous levels of Human CDCP1 (phospho-Tyr743) |
| Immunogen: | Synthesized phosho peptide around human CDCP1 (Tyr743) |
| Post Translational Modifications | Phosphorylated on tyrosine by kinases of the SRC family such as SRC and YES as well as by the protein kinase C gamma/PRKCG. Dephosphorylated by phosphotyrosine phosphatases. Also phosphorylated by suramin, a heparin analog. Tyrosine phosphorylated in response to dissociation of integrin alpha-6 beta-4 from laminin-5. N-glycosylated. A soluble form may also be produced by proteolytic cleavage at the cell surface (shedding). Another peptide of 80 kDa (p80) is present in cultured keratinocytes probably due to tryptic cleavage at an unidentified site on its N-terminal side. Converted to p80 by plasmin, a trypsin-like protease. |
| Function | May be involved in cell adhesion and cell matrix association. May play a role in the regulation of anchorage versus migration or proliferation versus differentiation via its phosphorylation. May be a novel marker for leukemia diagnosis and for immature hematopoietic stem cell subsets. Belongs to the tetraspanin web involved in tumor progression and metastasis. |
| Protein Name | Cub Domain-Containing Protein 1 Membrane Glycoprotein Gp140 Subtractive Immunization M Plus Hep3-Associated 135 Kda Protein Sima135 Transmembrane And Associated With Src Kinases Cd Antigen Cd318 |
| Cellular Localisation | Isoform 1: Cell Membrane Single-Pass Membrane Protein Shedding May Also Lead To A Soluble Peptide Isoform 3: Secreted |
| Alternative Antibody Names | Anti-Cub Domain-Containing Protein 1 antibody Anti-Membrane Glycoprotein Gp140 antibody Anti-Subtractive Immunization M Plus Hep3-Associated 135 Kda Protein antibody Anti-Sima135 antibody Anti-Transmembrane And Associated With Src Kinases antibody Anti-Cd Antigen Cd318 antibody Anti-CDCP1 antibody Anti-TRASK antibody Anti-UNQ2486 antibody Anti-PRO5773 antibody |
Information sourced from Uniprot.org