Anti-Phospho-CASP2-Ser157 antibody (123-172 aa) (STJ91157)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human Caspase 2 around the phosphorylation site of Ser157 at the amino acid range 123-172
General Information
| Short Description | Rabbit polyclonal anti-Phospho-Caspase-2-Ser157 (123-172 aa) for use in IHC, IF and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | IHC 1:100-1:300ELISA 1:10000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CASP2 |
| Gene ID | 835 |
| Uniprot ID | CASP2_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human Caspase 2 around the phosphorylation site of Ser157 at the amino acid range 123-172 |
| Immunogen Region | 123-172 aa |
| Specificity | Phospho-Caspase-2 (S157) Polyclonal Antibody detects endogenous levels of Caspase-2 protein only when phosphorylated at S157. |
Additional Info
| Post Translational Modifications | The mature protease can process its own propeptide, but not that of other caspases. |
| Function | Is a regulator of the cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival. Associates with PIDD1 and CRADD to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis in response to genotoxic stress. Isoform 1: Acts as a positive regulator of apoptosis. Isoform 2: Acts as a negative regulator of apoptosis. Isoform 3: May function as an endogenous apoptosis inhibitor that antagonizes caspase activation and cell death. |
| Protein Name | Caspase-2Casp-2Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 2Nedd-2Protease Ich-1 Cleaved Into - Caspase-2 Subunit P18 - Caspase-2 Subunit P13 - Caspase-2 Subunit P12 |
| Database Links | Reactome: R-HSA-168638Reactome: R-HSA-205025Reactome: R-HSA-6803207 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Caspase-2 antibodyAnti-Casp-2 antibodyAnti-Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 2 antibodyAnti-Nedd-2 antibodyAnti-Protease Ich-1 Cleaved Into - Caspase-2 Subunit P18 - Caspase-2 Subunit P13 - Caspase-2 Subunit P12 antibodyAnti-CASP2 antibodyAnti-ICH1 antibodyAnti-NEDD2 antibody |
Information sourced from Uniprot.org