• Immunohistochemistry analysis of paraffin-embedded human lung carcinoma, using Caspase 2 (Phospho-Ser157) Antibody. The picture on the right is blocked with the phospho peptide.
  • Immunohistochemical analysis of paraffin-embedded Human lung cancer. Antibody was diluted at 1:100 (4°C overnight). High-pressure and temperature Tris-EDTA, pH8.0 was used for antigen retrieval. Negetive contrl (right) obtaned from antibody was pre-absorbed by immunogen peptide.

Anti-Phospho-CASP2-Ser157 antibody (123-172 aa) (STJ91157)

SKU:
STJ91157

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: IHC/IF/ELISA
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Phospho-Caspase-2-Ser157 (123-172 aa) is suitable for use in Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: IHC 1:100-1:300
ELISA 1:10000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CASP2
Gene ID: 835
Uniprot ID: CASP2_HUMAN
Immunogen Region: 123-172 aa
Specificity: Phospho-Caspase-2 (S157) Polyclonal Antibody detects endogenous levels of Caspase-2 protein only when phosphorylated at S157.
Immunogen: The antiserum was produced against synthesized peptide derived from the human Caspase 2 around the phosphorylation site of Ser157 at the amino acid range 123-172
Post Translational Modifications The mature protease can process its own propeptide, but not that of other caspases.
Function Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival. Associates with PIDD1 and CRADD to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis in response to genotoxic stress.
Protein Name Caspase-2
Casp-2
Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 2
Nedd-2
Protease Ich-1 Cleaved Into - Caspase-2 Subunit P18 - Caspase-2 Subunit P13 - Caspase-2 Subunit P12
Database Links Reactome: R-HSA-168638
Reactome: R-HSA-205025
Reactome: R-HSA-6803207
Alternative Antibody Names Anti-Caspase-2 antibody
Anti-Casp-2 antibody
Anti-Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 2 antibody
Anti-Nedd-2 antibody
Anti-Protease Ich-1 Cleaved Into - Caspase-2 Subunit P18 - Caspase-2 Subunit P13 - Caspase-2 Subunit P12 antibody
Anti-CASP2 antibody
Anti-ICH1 antibody
Anti-NEDD2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance