| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Chicken/Human/Mouse/Rat/Xenopus |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Phospho-Arpc1b/p41-Arc-Thr-21 is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol |
| Purification: | Antigen Affinity Purified |
| Dilution Range: | WB 1:500 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ARPC1B |
| Gene ID: | 10095 |
| Uniprot ID: | ARC1B_HUMAN |
| Specificity: | The antibody detects a 41 kDa* protein corresponding to the molecular mass of Arpc1b on SDS-PAGE immunoblots of human A431 and mouse C2C12 treated with calyculin A. This reactivity is removed with lambda phosphatase treatment. |
| Immunogen: | Phospho-Arpc1b/p41-Arc (Thr-21) synthetic peptide (coupled to KLH) corresponding to amino acid residues surrounding threonine 21 in human Arpc1b. This peptide sequence is highly conserved in rat, mouse, chicken, and fish Arpc1b, and has some homology |
| Function | Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs). |
| Protein Name | Actin-Related Protein 2/3 Complex Subunit 1b Arp2/3 Complex 41 Kda Subunit P41-Arc |
| Database Links | Reactome: R-HSA-2029482 Reactome: R-HSA-3928662 Reactome: R-HSA-5663213 Reactome: R-HSA-9664422 |
| Cellular Localisation | Cytoplasm Cytoskeleton Nucleus |
| Alternative Antibody Names | Anti-Actin-Related Protein 2/3 Complex Subunit 1b antibody Anti-Arp2/3 Complex 41 Kda Subunit antibody Anti-P41-Arc antibody Anti-ARPC1B antibody Anti-ARC41 antibody |
Information sourced from Uniprot.org