| Function | Histone chaperone involved in single-strand and double-strand DNA break repair. Recruited to sites of DNA damage through interaction with branched poly-ADP-ribose chains, a polymeric post-translational modification synthesized transiently at sites of chromosomal damage to accelerate DNA strand break repair reactions. Following recruitment to DNA damage sites, acts as a histone chaperone that mediates histone eviction during DNA repair and promotes recruitment of histone variant MACROH2A1. Also has a nuclease activity: displays apurinic-apyrimidinic (AP) endonuclease and 3'-5' exonuclease activities in vitro. Also able to introduce nicks at hydroxyuracil and other types of pyrimidine base damage. Together with PARP3, promotes the retention of the LIG4-XRCC4 complex on chromatin and accelerate DNA ligation during non-homologous end-joining (NHEJ). Also acts as a negative regulator of cell pluripotency by promoting histone exchange. Required for the embryo implantation during the epithelial to mesenchymal transition in females. |
| Protein Name | Aprataxin And Pnk-Like FactorApurinic-Apyrimidinic Endonuclease AplfPnk And Aptx-Like Fha Domain-Containing ProteinXrcc1-Interacting Protein 1 |
| Cellular Localisation | NucleusChromosomeCytoplasmCytosolLocalizes To Dna Damage SitesAccumulates At Single-Strand Breaks And Double-Strand Breaks Via The Pbz-Type Zinc Fingers |
| Alternative Antibody Names | Anti-Aprataxin And Pnk-Like Factor antibodyAnti-Apurinic-Apyrimidinic Endonuclease Aplf antibodyAnti-Pnk And Aptx-Like Fha Domain-Containing Protein antibodyAnti-Xrcc1-Interacting Protein 1 antibodyAnti-APLF antibodyAnti-C2orf13 antibodyAnti-PALF antibodyAnti-XIP1 antibody |
Information sourced from Uniprot.org
