| Short Description : | Rabbit polyclonal anti-Phospho-Anaphase-promoting complex subunit 1-Ser355 (321-370 aa) for use in IHC, IF and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | IHC/IF/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range: | IHC 1:100-1:300ELISA 1:5000IF 1:50-200 |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ANAPC1 |
| Gene ID: | 64682 |
| Uniprot ID: | APC1_HUMAN |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human APC1 around the phosphorylation site of Ser355 at the amino acid range 321-370 |
| Immunogen Region: | 321-370 aa |
| Specificity: | Phospho-APC1 (S355) Polyclonal Antibody detects endogenous levels of APC1 protein only when phosphorylated at S355. |
| Function | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins. |
| Protein Name | Anaphase-Promoting Complex Subunit 1Apc1Cyclosome Subunit 1Mitotic Checkpoint RegulatorTestis-Specific Gene 24 Protein |
| Database Links | Reactome: R-HSA-141430Reactome: R-HSA-174048Reactome: R-HSA-174084Reactome: R-HSA-174154Reactome: R-HSA-174178Reactome: R-HSA-174184Reactome: R-HSA-176407Reactome: R-HSA-176408Reactome: R-HSA-176409Reactome: R-HSA-176412Reactome: R-HSA-179409Reactome: R-HSA-2467813Reactome: R-HSA-2559582Reactome: R-HSA-68867Reactome: R-HSA-69017Reactome: R-HSA-8853884Reactome: R-HSA-9687136Reactome: R-HSA-983168 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Anaphase-Promoting Complex Subunit 1 antibodyAnti-Apc1 antibodyAnti-Cyclosome Subunit 1 antibodyAnti-Mitotic Checkpoint Regulator antibodyAnti-Testis-Specific Gene 24 Protein antibodyAnti-ANAPC1 antibodyAnti-TSG24 antibody |
Information sourced from Uniprot.org
