Host: | Rabbit |
Applications: | IHC/IF/ELISA |
Reactivity: | Human/Mouse |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description : | Rabbit polyclonal antibody anti-Phospho-Anaphase-promoting complex subunit 1-Ser355 (321-370 aa) is suitable for use in Immunohistochemistry, Immunofluorescence and ELISA research applications. |
Clonality : | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Concentration: | 1 mg/mL |
Dilution Range: | IHC 1:100-1:300 ELISA 1:5000 IF 1:50-200 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | ANAPC1 |
Gene ID: | 64682 |
Uniprot ID: | APC1_HUMAN |
Immunogen Region: | 321-370 aa |
Specificity: | Phospho-APC1 (S355) Polyclonal Antibody detects endogenous levels of APC1 protein only when phosphorylated at S355. |
Immunogen: | The antiserum was produced against synthesized peptide derived from the human APC1 around the phosphorylation site of Ser355 at the amino acid range 321-370 |
Function | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins. |
Protein Name | Anaphase-Promoting Complex Subunit 1 Apc1 Cyclosome Subunit 1 Mitotic Checkpoint Regulator Testis-Specific Gene 24 Protein |
Database Links | Reactome: R-HSA-141430 Reactome: R-HSA-174048 Reactome: R-HSA-174084 Reactome: R-HSA-174154 Reactome: R-HSA-174178 Reactome: R-HSA-174184 Reactome: R-HSA-176407 Reactome: R-HSA-176408 Reactome: R-HSA-176409 Reactome: R-HSA-176412 Reactome: R-HSA-179409 Reactome: R-HSA-2467813 Reactome: R-HSA-2559582 Reactome: R-HSA-68867 Reactome: R-HSA-69017 Reactome: R-HSA-8853884 Reactome: R-HSA-9687136 Reactome: R-HSA-983168 |
Alternative Antibody Names | Anti-Anaphase-Promoting Complex Subunit 1 antibody Anti-Apc1 antibody Anti-Cyclosome Subunit 1 antibody Anti-Mitotic Checkpoint Regulator antibody Anti-Testis-Specific Gene 24 Protein antibody Anti-ANAPC1 antibody Anti-TSG24 antibody |
Information sourced from Uniprot.org