| Post Translational Modifications | Phosphorylated on serine and threonine residues in response to insulin, EGF and PDGF. Phosphorylation at Thr-37, Thr-46, Ser-65 and Thr-70, corresponding to the hyperphosphorylated form, is regulated by mTORC1 and abolishes binding to EIF4E. Ubiquitinated: when eIF4E levels are low, hypophosphorylated form is ubiquitinated by the BCR(KLHL25) complex, leading to its degradation and serving as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. Not ubiquitinated when hyperphosphorylated (at Thr-37, Thr-46, Ser-65 and Thr-70) or associated with eIF4E. |
| Function | Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways. |
| Protein Name | Eukaryotic Translation Initiation Factor 4e-Binding Protein 14e-Bp1Eif4e-Binding Protein 1Phosphorylated Heat- And Acid-Stable Protein Regulated By Insulin 1Phas-I |
| Database Links | Reactome: R-HSA-166208Reactome: R-HSA-72662 |
| Cellular Localisation | CytoplasmNucleusLocalization To The Nucleus Is Unaffected By Phosphorylation Status |
| Alternative Antibody Names | Anti-Eukaryotic Translation Initiation Factor 4e-Binding Protein 1 antibodyAnti-4e-Bp1 antibodyAnti-Eif4e-Binding Protein 1 antibodyAnti-Phosphorylated Heat- And Acid-Stable Protein Regulated By Insulin 1 antibodyAnti-Phas-I antibodyAnti-EIF4EBP1 antibody |
Information sourced from Uniprot.org
