Anti-PHKB antibody (854-1093) (STJ110321)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal PHKB (854-1093) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PHKB |
| Gene ID | 5257 |
| Uniprot ID | KPBB_HUMAN |
| Immunogen Region | 854-1093 |
| Immunogen Sequence | VIHIGWIISNNPELFSGMLK IRIGWIIHAMEYELQIRGGD KPALDLYQLSPSEVKQLLLD ILQPQQNGRCWLNRRQIDGS LNRTPTGFYDRVWQILERTP NGIIVAGKHLPQQPTLSDMT MYEMNFSLLVEDTLGNIDQP QYRQIVVELLMVVSIVLERN PELEFQDKVDLDRLVKEAFN EFQKDQSRLKEIEKQDDMTS FYNTPPLGKRGTCSYLTKAV MNLLLEGEVKPNNDDPCLI |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 854-1093 of human PHKB (NP_000284.1). |
Additional Info
| Post Translational Modifications | Ser-701 is probably phosphorylated by PKA. Although the final Cys may be farnesylated, the terminal tripeptide is probably not removed, and the C-terminus is not methylated. |
| Function | Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The beta chain acts as a regulatory unit and modulates the activity of the holoenzyme in response to phosphorylation. |
| Protein Name | Phosphorylase B Kinase Regulatory Subunit BetaPhosphorylase Kinase Subunit Beta |
| Database Links | Reactome: R-HSA-70221 |
| Cellular Localisation | Cell MembraneLipid-AnchorCytoplasmic Side |
| Alternative Antibody Names | Anti-Phosphorylase B Kinase Regulatory Subunit Beta antibodyAnti-Phosphorylase Kinase Subunit Beta antibodyAnti-PHKB antibody |
Information sourced from Uniprot.org