Anti-PHC3 antibody (100-300) (STJ116086)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal PHC3 (100-300) antibody for use in IF, ICC and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | IF/ICC:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PHC3 |
| Gene ID | 80012 |
| Uniprot ID | PHC3_HUMAN |
| Immunogen Region | 100-300 |
| Immunogen Sequence | LSSSQLQSLAAVQASLSSGR PSTSPTGSVTQQSSMSQTSI NLSTSPTPAQLISRSQASSS TSGSITQQTMLLGSTSPTLT ASQAQMYLRAQMLIFTPATT VAAVQSDIPVVSSSSSSSCQ SAATQVQNLTLRSQKLGVLS SSQNGPPKSTSQTQSLTICH NKTTVTSSKISQRDPSPESN KKGESPSLESRSTAVTRTSS I |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 100-300 of human PHC3 (NP_079223.3). |
Additional Info
| Function | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones.it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. |
| Protein Name | Polyhomeotic-Like Protein 3Early Development Regulatory Protein 3Homolog Of Polyhomeotic 3Hph3 |
| Database Links | Reactome: R-HSA-2559580Reactome: R-HSA-3108214Reactome: R-HSA-3899300Reactome: R-HSA-4551638Reactome: R-HSA-4570464Reactome: R-HSA-4655427Reactome: R-HSA-8939243Reactome: R-HSA-8943724Reactome: R-HSA-8953750 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Polyhomeotic-Like Protein 3 antibodyAnti-Early Development Regulatory Protein 3 antibodyAnti-Homolog Of Polyhomeotic 3 antibodyAnti-Hph3 antibodyAnti-PHC3 antibodyAnti-EDR3 antibodyAnti-PH3 antibody |
Information sourced from Uniprot.org