Anti-PHACTR1 antibody (154-380) (STJ11103185)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal PHACTR1 (154-380) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PHACTR1 |
| Gene ID | 221692 |
| Uniprot ID | PHAR1_HUMAN |
| Immunogen Region | 154-380 |
| Immunogen Sequence | IKRGVLKEIYDKDGELSISN EEDSLENGQSLSSSQLSLPA LSEMEPVPMPRDPCSYEVLQ PSDIMDGPDPGAPVKLPCLP VKLSPPLPPKKVMICMPVGG PDLSLVSYTAQKSGQQGVAQ HHHTVLPSQIQHQLQYGSHG QHLPSTTGSLPMHPSGCRMI DELNKTLAMTMQRLESSEQR VPCSTSYHSSGLHSGDGVTK AGPMGLPEIRQVPTVVIECD DNKENVP |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 154-380 of human PHACTR1 (NP_112210.1). |
Additional Info
| Tissue Specificity | Detected in umbilical vein endothelial cells. |
| Function | Binds actin monomers (G actin) and plays a role in multiple processes including the regulation of actin cytoskeleton dynamics, actin stress fibers formation, cell motility and survival, formation of tubules by endothelial cells, and regulation of PPP1CA activity. Involved in the regulation of cortical neuron migration and dendrite arborization. |
| Protein Name | Phosphatase And Actin Regulator 1 |
| Database Links | |
| Cellular Localisation | CytoplasmSynapseNucleusEnriched At SynapsesCytoplasmic In Resting CellsAnd Is Imported Into The Nucleus Upon Serum StimulationInteraction With Actin Prevents Nuclear Import |
| Alternative Antibody Names | Anti-Phosphatase And Actin Regulator 1 antibodyAnti-PHACTR1 antibodyAnti-KIAA1733 antibodyAnti-RPEL1 antibody |
Information sourced from Uniprot.org