| Short Description : | Rabbit polyclonal anti-Membrane-associated progesterone receptor component 2 (174-223 aa) for use in WB, ELISA and IHC in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA/IHC |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range: | WB 1:500-2000IHC-P 1:50-300ELISA 2000-20000 |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PGRMC2 |
| Gene ID: | 10424 |
| Uniprot ID: | PGRC2_HUMAN |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human PGRMC2 at the amino acid range 174-223 |
| Immunogen Region: | 174-223 aa |
| Specificity: | PGRMC2 Polyclonal Antibody detects endogenous levels of PGRMC2 protein. |
| Function | Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan. May serve as a universal non-classical progesterone receptor in the uterus (Probable). Intracellular heme chaperone required for delivery of labile, or signaling heme, to the nucleus. Plays a role in adipocyte function and systemic glucose homeostasis. In brown fat, which has a high demand for heme, delivery of labile heme in the nucleus regulates the activity of heme-responsive transcriptional repressors such as NR1D1 and BACH1. |
| Protein Name | Membrane-Associated Progesterone Receptor Component 2Progesterone Membrane-Binding ProteinSteroid Receptor Protein Dg6 |
| Database Links | Reactome: R-HSA-8980692Reactome: R-HSA-9013404Reactome: R-HSA-9013405Reactome: R-HSA-9013408Reactome: R-HSA-9013423Reactome: R-HSA-9707616 |
| Cellular Localisation | MembraneSingle-Pass Membrane ProteinNucleus EnvelopeEndoplasmic ReticulumSecreted |
| Alternative Antibody Names | Anti-Membrane-Associated Progesterone Receptor Component 2 antibodyAnti-Progesterone Membrane-Binding Protein antibodyAnti-Steroid Receptor Protein Dg6 antibodyAnti-PGRMC2 antibodyAnti-DG6 antibodyAnti-PMBP antibody |
Information sourced from Uniprot.org
