| Host: |
Rabbit |
| Applications: |
CM/ELISA/ICC/IF/IHC/WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PGCE (C-Term) is suitable for use in Confocal Microscopy, ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
FITC |
| Isotype: |
IgG |
| Purification: |
Affinity Purified |
| Concentration: |
0.75-1.20 µg/µl |
| Dilution Range: |
WB: 1:500DB: 1:10, 000ELISA: 1:10, 000IHC: 1:200ICC: 1:200IF: 1:200CFM: 1:200 |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
Gucy2e |
| Gene ID: |
79222 |
| Uniprot ID: |
GUC2E_RAT |
| Immunogen Region: |
C-Term |
| Immunogen: |
Synthetic C-terminal peptide corresponding to unique amino acid sequences on Particulate Guanylyl Cyclase E protein. |
| Tissue Specificity | Expressed in retina and enriched in photoreceptor outer segments. |
| Post Translational Modifications | There are 9 conserved cysteine residues in sensory guanylate cyclases, 6 in the extracellular domain, which may be involved in intra- or interchain disulfide bonds. |
| Function | Catalyzes the synthesis of cyclic GMP (cGMP) in rods and cones of photoreceptors. Plays an essential role in phototransduction, by mediating cGMP replenishment. May also participate in the trafficking of membrane-asociated proteins to the photoreceptor outer segment membrane. |
| Protein Name | Retinal Guanylyl Cyclase 1Retgc-1Guanylate Cyclase 2eGuanylyl Cyclase Gc-E |
| Database Links | Reactome: R-RNO-2514859 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane ProteinPhotoreceptor Outer Segment MembraneEndoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-Retinal Guanylyl Cyclase 1 antibodyAnti-Retgc-1 antibodyAnti-Guanylate Cyclase 2e antibodyAnti-Guanylyl Cyclase Gc-E antibodyAnti-Gucy2e antibodyAnti-Guc2e antibodyAnti-Gucy2d antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
