| Host: |
Goat |
| Applications: |
Pep-ELISA/WB/IHC |
| Reactivity: |
Human/Mouse/Rat/Dog |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-PERP (C-Term) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
Peptide ELISA: antibody detection limit dilution 1:64000.WB: Approx 20kDa band observed in Human Liver lysates (calculated MW of 21.4kDa according to NP_071404.2). Recommended concentration: 1-3µg/ml.IHC: Paraffin embedded Human Skin. Recom |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
PERP |
| Gene ID: |
64065 |
| Uniprot ID: |
PERP_HUMAN |
| Immunogen Region: |
C-Term |
| Accession Number: |
NP_071404.2 |
| Immunogen Sequence: |
CLPNYEDDLLGNAK |
| Function | Component of intercellular desmosome junctions. Plays a role in stratified epithelial integrity and cell-cell adhesion by promoting desmosome assembly. Thereby plays a role in barrier function of the skin against infection. Plays a role in mammary epithelial tissue homeostasis and remodeling during and after pregnancy, potentially via its involvement in desmosome cell-cell junctions. Required for tooth enamel development via facilitating desmosome-mediated ameloblast adhesion to the stratum intermedium during the transitional stage of amelogenesis. May also play a role in downstream transcriptional regulation of other genes involved in amelogenesis such as AMBN, ENAM, MMP20 and KLK4. Plays a role as an effector in the TP53-dependent apoptotic pathway. Positively regulates apoptosis in T-helper 17 (Th17) cell populations via caspase-dependent signaling. Promotes neutrophil transepithelial migration in response to chemoattractants such as hepoxilin A3 (HXA3), N-Formylmethionyl-leucyl-phenylalanine (fMLP) and CXCL8/IL-8. Required for neutrophil transepithelial migration in response to S.typhimurium infection. May act as a positive regulator of endothelial cell apoptosis in response to blood flow-derived sheer stress. |
| Protein Name | P53 Apoptosis Effector Related To Pmp-22Keratinocyte-Associated Protein 1Kcp-1P53-Induced Protein Pigpc1Transmembrane Protein Thw |
| Database Links | Reactome: R-HSA-6803205Reactome: R-HSA-6809371 |
| Cellular Localisation | Cell JunctionDesmosomeCell MembraneMulti-Pass Membrane ProteinCytoplasmAssociated With DesmosomesColocalizes With Krt14 In The Cell MembraneClusters In A Punctate Pattern Throughout The Epithelial CytoplasmIn Response To STyphimurium Infection |
| Alternative Antibody Names | Anti-P53 Apoptosis Effector Related To Pmp-22 antibodyAnti-Keratinocyte-Associated Protein 1 antibodyAnti-Kcp-1 antibodyAnti-P53-Induced Protein Pigpc1 antibodyAnti-Transmembrane Protein Thw antibodyAnti-PERP antibodyAnti-KCP1 antibodyAnti-KRTCAP1 antibodyAnti-PIGPC1 antibodyAnti-THW antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
