Anti-Peroxiredoxin-5 antibody (190-204 aa) (STJA0040944)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeMixed
ImmunogenA synthetic peptide (VKALNVEPDGTGLTC) corresponding to region (190-204 aa) of human Peroxiredoxin-5 conjugated to KLH. Human, mouse and rat sequences of this peptide are identical.
General Information
| Short Description | Rabbit polyclonal anti-Peroxiredoxin-5 (190-204 aa) for use in ELISA, IHC-F, IHC-P and WB in Human and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA/IHC-F/IHC-P/WB |
| Host | Rabbit |
| Reactivity | Human/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | Mixed |
| Conjugation | Unconjugated |
| Purification | Whole serum |
| Dilution Range | WB 1:1000-1:2000IHC 1:50-1:100 |
| Formulation | Lyophilized serum with 0.02% thimerosal |
| Storage Instruction | Spin vial briefly before opening. Reconstitute in 100 ยตL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material. At least 12 months after purchase at 2-8ยฐC (lyophilized formulations). After reconstitution, aliquot and store at |
Target Information
| Gene Symbol | PRDX5 |
| Gene ID | 25824 |
| Uniprot ID | PRDX5_HUMAN |
| Immunogen | A synthetic peptide (VKALNVEPDGTGLTC) corresponding to region (190-204 aa) of human Peroxiredoxin-5 conjugated to KLH. Human, mouse and rat sequences of this peptide are identical. |
| Immunogen Region | 190-204 aa |
| Immunogen Sequence | Human |
| Specificity | Human Peroxiredoxin-5 no cross reactivity to other family members. |
Additional Info
| Tissue Specificity | Widely expressed. |
| Post Translational Modifications | S-palmitoylated. Palmitoylation occurs on the active site, inhibiting its reactivity.therefore PRDX5 palmitoylation status determines its antioxidant capacity. Isoform Mitochondrial: S-palmitoylated. Depalmitoylated by ABHD10. |
| Function | Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. |
| Protein Name | Peroxiredoxin-5 - MitochondrialAlu Corepressor 1Antioxidant Enzyme B166Aoeb166Liver Tissue 2d-Page Spot 71bPlpPeroxiredoxin VPrx-VPeroxisomal Antioxidant EnzymeTpx Type ViThioredoxin Peroxidase Pmp20Thioredoxin-Dependent Peroxiredoxin 5 |
| Database Links | Reactome: R-HSA-3299685Reactome: R-HSA-5628897 P30044-2 |
| Cellular Localisation | Isoform Mitochondrial: MitochondrionIsoform Cytoplasmic+Peroxisomal: CytoplasmPeroxisome MatrixImported Into Peroxisomes Via Peroxisomal Targeting Signal 1 Receptor Pex5 |
| Alternative Antibody Names | Anti-Peroxiredoxin-5 - Mitochondrial antibodyAnti-Alu Corepressor 1 antibodyAnti-Antioxidant Enzyme B166 antibodyAnti-Aoeb166 antibodyAnti-Liver Tissue 2d-Page Spot 71b antibodyAnti-Plp antibodyAnti-Peroxiredoxin V antibodyAnti-Prx-V antibodyAnti-Peroxisomal Antioxidant Enzyme antibodyAnti-Tpx Type Vi antibodyAnti-Thioredoxin Peroxidase Pmp20 antibodyAnti-Thioredoxin-Dependent Peroxiredoxin 5 antibodyAnti-PRDX5 antibodyAnti-ACR1 antibodyAnti-SBBI10 antibody |
Information sourced from Uniprot.org