Anti-Peroxiredoxin 3/PRDX3 antibody (63-256aa) [AT1F8] (STJA0041781)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG3k
ImmunogenRecombinant human Peroxiredoxin3 (63-256aa) purified from E. coli
General Information
| Short Description | Mouse monoclonal anti-Peroxiredoxin 3/PRDX3 (63-256aa) for use in ELISA, WB, ICC and IF in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA/WB/ICC/IF |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | AT1F8 |
| Isotype | IgG3k |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | By protein-A affinity chromatography |
| Formulation | Liquid in phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PRDX3 |
| Gene ID | 10935 |
| Uniprot ID | PRDX3_HUMAN |
| Accession Number | NP_006784 |
| Immunogen | Recombinant human Peroxiredoxin3 (63-256aa) purified from E. coli |
| Immunogen Region | 63-256aa |
Additional Info
| Post Translational Modifications | Phosphorylated by LRRK2.phosphorylation reduces perodixase activity. The enzyme can be inactivated by further oxidation of the cysteine sulfenic acid (C(P)-SOH) to sulphinic acid (C(P)-SO2H) and sulphonic acid (C(P)-SO3H) instead of its condensation to a disulfide bond. S-palmitoylated. |
| Function | Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol. Required for the maintenance of physical strength. |
| Protein Name | Thioredoxin-Dependent Peroxide Reductase - MitochondrialAntioxidant Protein 1Aop-1Hbc189Peroxiredoxin IiiPrx-IiiPeroxiredoxin-3Protein Mer5 HomologThioredoxin-Dependent Peroxiredoxin 3 |
| Database Links | Reactome: R-HSA-3299685 |
| Cellular Localisation | MitochondrionCytoplasmEarly EndosomeLocalizes To Early Endosomes In A Rps6kc1-Dependent Manner |
| Alternative Antibody Names | Anti-Thioredoxin-Dependent Peroxide Reductase - Mitochondrial antibodyAnti-Antioxidant Protein 1 antibodyAnti-Aop-1 antibodyAnti-Hbc189 antibodyAnti-Peroxiredoxin Iii antibodyAnti-Prx-Iii antibodyAnti-Peroxiredoxin-3 antibodyAnti-Protein Mer5 Homolog antibodyAnti-Thioredoxin-Dependent Peroxiredoxin 3 antibodyAnti-PRDX3 antibodyAnti-AOP1 antibody |
Information sourced from Uniprot.org