| Host: | Rabbit |
| Applications: | ICC/WB |
| Reactivity: | Bovine/Human/Mouse/Pig/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal anti-Peripherin (Full-Length) for use in ICC and WB in Bovine, Human, Mouse, Pig and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | Mixed |
| Formulation: | Lyophilized with sodium azide. |
| Purification: | Whole serum |
| Dilution Range: | WB 1:2000-1:10000ICC 1:1000-1:2000 |
| Storage Instruction: | Spin vial briefly before opening. Reconstitute with 50 µL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material. After reconstitution of lyophilized antibody, aliquot and store at-20°C for a higher stability. Avoid freeze-tha |
| Gene Symbol: | PrphUniprot ID=PERI_RAT" |
| Immunogen Region: | Full-Length |
| Specificity: | The specificity of this antibody has been confirmed by WB. This antibody detects ~57 kDa Peripherin protein and a smaller molecule derived from Peripherin at ~48 kDa. Hu, rat, Ms, Fel, Rb. Predicted to react with other mammalian tissue. |
| Immunogen: | Recombinant full length Peripherin protein expressed in and purified from E.coli. |
| Immunogen Sequence: | Human |
| Tissue Specificity | Expressed in hypoglossal motor neurons (at protein level). Expressed in the small and large sensory neurons of the dorsal root ganglion (at protein level). Expressed in cutaneous and muscular sensory neurons. |
| Post Translational Modifications | Phosphorylated.phosphorylation increases after nerve injury in regenerating neurons. |
| Function | Class-III neuronal intermediate filament protein. My form an independent structural network without the involvement of other neurofilaments or may cooperate with the neuronal intermediate filament proteins NEFL, NEFH, NEFM and INA to form a filamentous network. Assembly of the neuronal intermediate filaments may be regulated by RAB7A. Plays a role in the development of unmyelinated sensory neurons. May be involved in axon elongation and axon regeneration after injury. Inhibits neurite extension in type II spiral ganglion neurons in the cochlea. |
| Protein Name | Peripherin |
| Cellular Localisation | CytoplasmCytoskeletonCell ProjectionAxonPerikaryon |
| Alternative Antibody Names | Anti-Peripherin antibodyAnti-Prph antibodyAnti-Prph1 antibody |
Information sourced from Uniprot.org