| Host: | Goat |
| Applications: | Pep-ELISA/WB |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-periostin (112-125) is suitable for use in ELISA and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:128000.WB: Approx 85kDa band observed in Human Breast cancer lysates (calculated MW of 93.3kDa according to NP_006466.2). Recommended concentration: 0.1-0.3µg/ml. |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | POSTN |
| Gene ID: | 10631 |
| Uniprot ID: | POSTN_HUMAN |
| Immunogen Region: | 112-125 |
| Accession Number: | NP_006466.2; NP_001129406.1; NP_001129407.1; NP_001129408.1 |
| Specificity: | This antibody is expected to recognize all reported isoforms (NP_006466.2; NP_001129406.1; NP_001129407.1; NP_001129408.1). |
| Immunogen Sequence: | TTQRYSDASKLREE |
| Post Translational Modifications | Gamma-carboxylation is controversial. Gamma-carboxyglutamated.gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation.this may be required for calcium binding. According to a more recent report, does not contain vitamin K-dependent gamma-carboxyglutamate residues. |
| Function | Induces cell attachment and spreading and plays a role in cell adhesion. Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic activation of lysyl oxidase LOX. |
| Protein Name | PeriostinPnOsteoblast-Specific Factor 2Osf-2 |
| Cellular Localisation | Golgi ApparatusSecretedExtracellular SpaceExtracellular MatrixColocalizes With Bmp1 In The Golgi |
| Alternative Antibody Names | Anti-Periostin antibodyAnti-Pn antibodyAnti-Osteoblast-Specific Factor 2 antibodyAnti-Osf-2 antibodyAnti-POSTN antibodyAnti-OSF2 antibody |
Information sourced from Uniprot.org