Anti-PELI2 antibody (STJA0009299)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human PELI2
General Information
| Short Description | Rabbit polyclonal anti-E3 ubiquitin-protein ligase pellino homolog 2 for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PELI2 |
| Gene ID | 57161 |
| Uniprot ID | PELI2_HUMAN |
| Immunogen | Synthesized peptide derived from human PELI2 |
| Specificity | This antibody detects endogenous levels of PELI2 at Human, Mouse |
Additional Info
| Function | E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination. May be important for LPS- and IL1B-induced MAP3K7-dependent, but not MAP3K3-dependent, NF-kappa-B activation. Can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1. |
| Protein Name | E3 Ubiquitin-Protein Ligase Pellino Homolog 2Pellino-2Ring-Type E3 Ubiquitin Transferase Pellino Homolog 2 |
| Database Links | Reactome: R-HSA-9020702Reactome: R-HSA-937039Reactome: R-HSA-975144 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Pellino Homolog 2 antibodyAnti-Pellino-2 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Pellino Homolog 2 antibodyAnti-PELI2 antibody |
Information sourced from Uniprot.org