Anti-PEG10 antibody (STJA0038034)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenRecombinant protein of human PEG10
General Information
| Short Description | Rabbit monoclonal anti-PEG10 for use in IHC-P in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC-P |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Purified |
| Dilution Range | IHC 1:100-1:200 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | PEG10 |
| Gene ID | 23089 |
| Uniprot ID | PEG10_HUMAN |
| Immunogen | Recombinant protein of human PEG10 |
Additional Info
| Tissue Specificity | Expressed in the cytotrophoblast layer but not in the overlying syncytiotrophoblast of the placenta. Expressed in prostate and breast carcinomas but not in normal breast and prostate epithelial cells. Expressed in the Hep-G2 cell line (at protein level). Expressed in brain, liver, spleen, kidney, thymus, lung, ovary, testis, reactive lymph node, skeletal muscle, adipose tissue and placenta. Expressed in pancreatic and hepatocellular carcinomas (HCC). |
| Post Translational Modifications | Isoform 1: Undergoes proteolytic cleavage. |
| Function | Retrotransposon-derived protein that binds its own mRNA and self-assembles into virion-like capsids. Forms virion-like extracellular vesicles that encapsulate their own mRNA and are released from cells, enabling intercellular transfer of PEG10 mRNA. Binds its own mRNA in the 5'-UTR region, in the region near the boundary between the nucleocapsid (NC) and protease (PRO) coding sequences and in the beginning of the 3'-UTR region. Involved in placenta formation: required for trophoblast stem cells differentiation. Involved at the immediate early stage of adipocyte differentiation. Overexpressed in many cancers and enhances tumor progression: promotes cell proliferation by driving cell cycle progression from G0/G1. Enhances cancer progression by inhibiting the TGF-beta signaling, possibly via interaction with the TGF-beta receptor ACVRL1. May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter.additional evidences are however required to confirm this result. |
| Protein Name | Retrotransposon-Derived Protein Peg10Embryonal Carcinoma Differentiation-Regulated ProteinMammalian Retrotransposon-Derived Protein 2Myelin Expression Factor 3-Like Protein 1Mef3-Like Protein 1Paternally Expressed Gene 10 ProteinRetrotransposon Gag Domain-Containing Protein 3Retrotransposon-Derived Gag-Like PolyproteinTy3/Gypsy-Like Protein |
| Database Links | |
| Cellular Localisation | Extracellular Vesicle MembraneCytoplasmNucleusForms Virion-Like Extracellular Vesicles That Are Released From CellsDetected Predominantly In The Cytoplasm Of Breast And Prostate CarcinomasIn Hepatocellular Carcinoma (Hcc) And B-Cell Chronic Lymphocytic Leukemia (B-Cll) Cells And In The Hep-G2 Cell Line |
| Alternative Antibody Names | Anti-Retrotransposon-Derived Protein Peg10 antibodyAnti-Embryonal Carcinoma Differentiation-Regulated Protein antibodyAnti-Mammalian Retrotransposon-Derived Protein 2 antibodyAnti-Myelin Expression Factor 3-Like Protein 1 antibodyAnti-Mef3-Like Protein 1 antibodyAnti-Paternally Expressed Gene 10 Protein antibodyAnti-Retrotransposon Gag Domain-Containing Protein 3 antibodyAnti-Retrotransposon-Derived Gag-Like Polyprotein antibodyAnti-Ty3/Gypsy-Like Protein antibodyAnti-PEG10 antibodyAnti-EDR antibodyAnti-KIAA1051e antibodyAnti-MAR2 antibodyAnti-MART2 antibodyAnti-MEF3L1 antibodyAnti-RGAG3 antibody |
Information sourced from Uniprot.org