| Post Translational Modifications | Isoform 1: Undergoes proteolytic cleavage. |
| Function | Retrotransposon-derived protein that binds its own mRNA and self-assembles into virion-like capsids. Forms virion-like extracellular vesicles that encapsulate their own mRNA and are released from cells, enabling intercellular transfer of PEG10 mRNA. Binds its own mRNA in the 5'-UTR region, in the region near the boundary between the nucleocapsid (NC) and protease (PRO) coding sequences and in the beginning of the 3'-UTR region. Involved in placenta formation: required for trophoblast stem cells differentiation. Involved at the immediate early stage of adipocyte differentiation. Overexpressed in many cancers and enhances tumor progression: promotes cell proliferation by driving cell cycle progression from G0/G1. Enhances cancer progression by inhibiting the TGF-beta signaling, possibly via interaction with the TGF-beta receptor ACVRL1. May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter.additional evidences are however required to confirm this result. |
| Protein Name | Retrotransposon-Derived Protein Peg10Embryonal Carcinoma Differentiation-Regulated ProteinMammalian Retrotransposon-Derived Protein 2Myelin Expression Factor 3-Like Protein 1Mef3-Like Protein 1Paternally Expressed Gene 10 ProteinRetrotransposon Gag Domain-Containing Protein 3Retrotransposon-Derived Gag-Like PolyproteinTy3/Gypsy-Like Protein |
| Cellular Localisation | Extracellular Vesicle MembraneCytoplasmNucleusForms Virion-Like Extracellular Vesicles That Are Released From CellsDetected Predominantly In The Cytoplasm Of Breast And Prostate CarcinomasIn Hepatocellular Carcinoma (Hcc) And B-Cell Chronic Lymphocytic Leukemia (B-Cll) Cells And In The Hep-G2 Cell Line |
| Alternative Antibody Names | Anti-Retrotransposon-Derived Protein Peg10 antibodyAnti-Embryonal Carcinoma Differentiation-Regulated Protein antibodyAnti-Mammalian Retrotransposon-Derived Protein 2 antibodyAnti-Myelin Expression Factor 3-Like Protein 1 antibodyAnti-Mef3-Like Protein 1 antibodyAnti-Paternally Expressed Gene 10 Protein antibodyAnti-Retrotransposon Gag Domain-Containing Protein 3 antibodyAnti-Retrotransposon-Derived Gag-Like Polyprotein antibodyAnti-Ty3/Gypsy-Like Protein antibodyAnti-PEG10 antibodyAnti-EDR antibodyAnti-KIAA1051e antibodyAnti-MAR2 antibodyAnti-MART2 antibodyAnti-MEF3L1 antibodyAnti-RGAG3 antibody |
Information sourced from Uniprot.org
