Host: | Rabbit |
Applications: | WB/IHC/IF/ELISA |
Reactivity: | Human/Mouse/Rat/Monkey |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description : | Rabbit polyclonal antibody anti-Astrocytic phosphoprotein PEA-15 (81-130 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
Clonality : | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Concentration: | 1 mg/mL |
Dilution Range: | WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:40000 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | PEA15 |
Gene ID: | 8682 |
Uniprot ID: | PEA15_HUMAN |
Immunogen Region: | 81-130 aa |
Specificity: | PEA-15 Polyclonal Antibody detects endogenous levels of PEA-15 protein. |
Immunogen: | The antiserum was produced against synthesized peptide derived from the human PEA-15 at the amino acid range 81-130 |
Post Translational Modifications | Phosphorylated by protein kinase C and calcium-calmodulin-dependent protein kinase. These phosphorylation events are modulated by neurotransmitters or hormones. |
Function | Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm. Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface. |
Protein Name | Astrocytic Phosphoprotein Pea-1515 Kda Phosphoprotein Enriched In AstrocytesPhosphoprotein Enriched In DiabetesPed |
Database Links | Reactome: R-HSA-112409Reactome: R-HSA-5673001 |
Cellular Localisation | CytoplasmAssociated With Microtubules |
Alternative Antibody Names | Anti-Astrocytic Phosphoprotein Pea-15 antibodyAnti-15 Kda Phosphoprotein Enriched In Astrocytes antibodyAnti-Phosphoprotein Enriched In Diabetes antibodyAnti-Ped antibodyAnti-PEA15 antibody |
Information sourced from Uniprot.org