Anti-PDP2 antibody (67-250) (STJ116626)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal PDP2 (67-250) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PDP2 |
| Gene ID | 57546 |
| Uniprot ID | PDP2_HUMAN |
| Immunogen Region | 67-250 |
| Immunogen Sequence | STEEDDFHLQLSPEQINEVL RAGETTHKILDLESRVPNSV LRFESNQLAANSPVEDRRGV ASCLQTNGLMFGIFDGHGGH ACAQAVSERLFYYVAVSLMS HQTLEHMEGAMESMKPLLPI LHWLKHPGDSIYKDVTSVHL DHLRVYWQELLDLHMEMGLS IEEALMYSFQRLDSDISLEI QAPL |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 67-250 of human PDP2 (NP_065837.1). |
Additional Info
| Function | Mitochondrial enzyme that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex (PDC), thereby stimulating the conversion of pyruvate into acetyl-CoA. Acts as a crucial regulator of T cell metabolism and function, with a particular focus on T-helper Th17. |
| Protein Name | Pyruvate Dehydrogenase Acetyl-Transferring-Phosphatase 2 - MitochondrialPdp 2Pyruvate Dehydrogenase Phosphatase Catalytic Subunit 2Pdpc 2 |
| Database Links | Reactome: R-HSA-204174 |
| Cellular Localisation | Mitochondrion |
| Alternative Antibody Names | Anti-Pyruvate Dehydrogenase Acetyl-Transferring-Phosphatase 2 - Mitochondrial antibodyAnti-Pdp 2 antibodyAnti-Pyruvate Dehydrogenase Phosphatase Catalytic Subunit 2 antibodyAnti-Pdpc 2 antibodyAnti-PDP2 antibodyAnti-KIAA1348 antibody |
Information sourced from Uniprot.org