| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PDP2 |
| Gene ID: | 57546 |
| Uniprot ID: | PDP2_HUMAN |
| Immunogen Region: | 67-250 |
| Immunogen Sequence: | STEEDDFHLQLSPEQINEVL RAGETTHKILDLESRVPNSV LRFESNQLAANSPVEDRRGV ASCLQTNGLMFGIFDGHGGH ACAQAVSERLFYYVAVSLMS HQTLEHMEGAMESMKPLLPI LHWLKHPGDSIYKDVTSVHL DHLRVYWQELLDLHMEMGLS IEEALMYSFQRLDSDISLEI QAPL |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 67-250 of human PDP2 (NP_065837.1). |
| Function | Mitochondrial enzyme that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex (PDC), thereby stimulating the conversion of pyruvate into acetyl-CoA. Acts as a crucial regulator of T cell metabolism and function, with a particular focus on T-helper Th17. |
| Protein Name | Pyruvate Dehydrogenase Acetyl-Transferring-Phosphatase 2 - MitochondrialPdp 2Pyruvate Dehydrogenase Phosphatase Catalytic Subunit 2Pdpc 2 |
| Database Links | Reactome: R-HSA-204174 |
| Cellular Localisation | Mitochondrion |
| Alternative Antibody Names | Anti-Pyruvate Dehydrogenase Acetyl-Transferring-Phosphatase 2 - Mitochondrial antibodyAnti-Pdp 2 antibodyAnti-Pyruvate Dehydrogenase Phosphatase Catalytic Subunit 2 antibodyAnti-Pdpc 2 antibodyAnti-PDP2 antibodyAnti-KIAA1348 antibody |
Information sourced from Uniprot.org
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