Host: | Rabbit |
Applications: | WB/ELISA |
Reactivity: | Human/Rat/Mouse |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description : | Rabbit polyclonal antibody anti-Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial (310-390 aa) is suitable for use in Western Blot and ELISA research applications. |
Clonality : | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Concentration: | 1 mg/mL |
Dilution Range: | WB 1:500-2000ELISA 1:5000-20000 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | PDHA2 |
Gene ID: | 5161 |
Uniprot ID: | ODPAT_HUMAN |
Immunogen Region: | 310-390 aa |
Specificity: | ODPAT Polyclonal Antibody detects endogenous levels of protein. |
Immunogen: | Synthesized peptide derived from the human protein at the amino acid range 310-390 |
Post Translational Modifications | Phosphorylation at Ser-291, Ser-293 and Ser-298 by PDK family kinases inactivates the enzyme.for this phosphorylation at a single site is sufficient. Phosphorylation at Ser-293 interferes with access to active site, and thereby inactivates the enzyme. Dephosphorylation at all three sites, i.e. at Ser-291, Ser-293 and Ser-298, is required for reactivation. |
Function | The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. |
Protein Name | Pyruvate Dehydrogenase E1 Component Subunit Alpha - Testis-Specific Form - MitochondrialPdhe1-A Type Ii |
Database Links | Reactome: R-HSA-204174Reactome: R-HSA-5362517Reactome: R-HSA-9861559 |
Cellular Localisation | Mitochondrion Matrix |
Alternative Antibody Names | Anti-Pyruvate Dehydrogenase E1 Component Subunit Alpha - Testis-Specific Form - Mitochondrial antibodyAnti-Pdhe1-A Type Ii antibodyAnti-PDHA2 antibodyAnti-PDHAL antibody |
Information sourced from Uniprot.org