| Post Translational Modifications | Activated by proteolytic cleavage. Proteolytic removal of the N-terminal CUB domain releasing the core domain is necessary for unmasking the receptor-binding epitopes of the core domain. Cleavage after Arg-247 or Arg-249 by urokinase plasminogen activator gives rise to the active form. |
| Function | Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix. |
| Protein Name | Platelet-Derived Growth Factor DPdgf-DIris-Expressed Growth FactorSpinal Cord-Derived Growth Factor BScdgf-B Cleaved Into - Platelet-Derived Growth Factor D - Latent FormPdgfd Latent Form - Platelet-Derived Growth Factor D - Receptor-Binding FormPdgfd Receptor-Binding Form |
| Database Links | Reactome: R-HSA-186797 |
| Cellular Localisation | SecretedReleased By Platelets Upon Wounding |
| Alternative Antibody Names | Anti-Platelet-Derived Growth Factor D antibodyAnti-Pdgf-D antibodyAnti-Iris-Expressed Growth Factor antibodyAnti-Spinal Cord-Derived Growth Factor B antibodyAnti-Scdgf-B Cleaved Into - Platelet-Derived Growth Factor D - Latent Form antibodyAnti-Pdgfd Latent Form - Platelet-Derived Growth Factor D - Receptor-Binding Form antibodyAnti-Pdgfd Receptor-Binding Form antibodyAnti-PDGFD antibodyAnti-IEGF antibodyAnti-SCDGFB antibodyAnti-MSTP036 antibodyAnti-UNQ1899 antibodyAnti-PRO4345 antibody |
Information sourced from Uniprot.org
