• Western blot analysis of lysates from Mouse heart using PDGFD Rabbit polyclonal antibody (STJ11105297) at 1:2000 dilution. Secondary antibody:HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25  Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection:ECL Basic Kit. Exposuretime:45s.

Anti-PDGFD antibody (19-307) (STJ11105297)

SKU:
STJ11105297

Current Stock:
Host: Rabbit
Applications: WB
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Platelet-Derived Growth Factor D (19-307) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.05% Proclin300, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:1000-1:5000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: PDGFD
Gene ID: 80310
Uniprot ID: PDGFD_HUMAN
Immunogen Region: 19-307
Immunogen: Recombinant Protein corresponding to a sequence within amino acids 19-307 of human PDGFD (NP_079484.1).
Immunogen Sequence: RDTSATPQSASIKALRNANL RRDESNHLTDLYRRDETIQV KGNGYVQSPRFPNSYPRNLL LTWRLHSQENTRIQLVFDNQ FGLEEAENDICRYDFVEVED ISETSTIIRGRWCGHKEVPP RIKSRTNQIKITFKSDDYFV AKPGFKIYYSLLEDFQPAAA SETNWESVTSSISGVSYNSP SVTDPTLIADALDKKIAEFD TVEDLLKYFNPESWQEDLEN MYLDTPRYRGRSYHDRKSK
Tissue Specificity Expressed at high levels in the heart, pancreas, adrenal gland and ovary and at low levels in placenta, liver, kidney, prostate, testis, small intestine, spleen and colon. In the kidney, expressed by the visceral epithelial cells of the glomeruli. A widespread expression is also seen in the medial smooth muscle cells of arteries and arterioles, as well as in smooth muscle cells of vasa rectae in the medullary area. Expressed in the adventitial connective tissue surrounding the suprarenal artery. In chronic obstructive nephropathy, a persistent expression is seen in glomerular visceral epithelial cells and vascular smooth muscle cells, as well as de novo expression by periglomerular interstitial cells and by some neointimal cells of atherosclerotic vessels. Expression in normal prostate is seen preferentially in the mesenchyme of the gland while expression is increased and more profuse in prostate carcinoma. Expressed in many ovarian, lung, renal and brain cancer-derived cell lines.
Post Translational Modifications Activated by proteolytic cleavage. Proteolytic removal of the N-terminal CUB domain releasing the core domain is necessary for unmasking the receptor-binding epitopes of the core domain. Cleavage after Arg-247 or Arg-249 by urokinase plasminogen activator gives rise to the active form.
Function Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix.
Protein Name Platelet-Derived Growth Factor D
Pdgf-D
Iris-Expressed Growth Factor
Spinal Cord-Derived Growth Factor B
Scdgf-B Cleaved Into - Platelet-Derived Growth Factor D - Latent Form
Pdgfd Latent Form - Platelet-Derived Growth Factor D - Receptor-Binding Form
Pdgfd Receptor-Binding Form
Database Links Reactome: R-HSA-186797
Cellular Localisation Secreted
Released By Platelets Upon Wounding
Alternative Antibody Names Anti-Platelet-Derived Growth Factor D antibody
Anti-Pdgf-D antibody
Anti-Iris-Expressed Growth Factor antibody
Anti-Spinal Cord-Derived Growth Factor B antibody
Anti-Scdgf-B Cleaved Into - Platelet-Derived Growth Factor D - Latent Form antibody
Anti-Pdgfd Latent Form - Platelet-Derived Growth Factor D - Receptor-Binding Form antibody
Anti-Pdgfd Receptor-Binding Form antibody
Anti-PDGFD antibody
Anti-IEGF antibody
Anti-SCDGFB antibody
Anti-MSTP036 antibody
Anti-UNQ1899 antibody
Anti-PRO4345 antibody

Information sourced from Uniprot.org

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