| Host: | Rabbit |
| Applications: | CM/ELISA/ICC/IF/IHC/IP/WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-PDE7A is suitable for use in Confocal Microscopy, ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | FITC |
| Isotype: | IgG |
| Formulation: | Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide). |
| Purification: | Affinity Purified |
| Concentration: | 0.5 µg/µl |
| Dilution Range: | WB: 1:500DB: 1:10, 000ELISA: 1:10, 000IP: 1:250IHC: 1:100-1:250ICC: 1:100-1:250IF: 1:100-1:250CFM: 1:100-1:250 |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: | PDE7A |
| Gene ID: | 5150 |
| Uniprot ID: | PDE7A_HUMAN |
| Specificity: | This antibody is specific for PDE7A variants and will not cross-react with PDE7B or other PDE family members. |
| Immunogen: | Synthetic cyclic peptide common to all PDE7A variants. |
| Tissue Specificity | Isoform PDE7A1: Found at high levels in skeletal muscle and at low levels in a variety of tissues including brain and heart. It is expressed as well in two T-cell lines. Isoform PDE7A2: Found abundantly in skeletal muscle and at low levels in heart. |
| Function | Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May have a role in muscle signal transduction. |
| Protein Name | High Affinity 3' -5'-Cyclic-Amp Phosphodiesterase 7aHcp1Tm22Camp-Specific Phosphodiesterase 7a |
| Database Links | Reactome: R-HSA-418555 |
| Cellular Localisation | Isoform Pde7a1: CytoplasmCytosolPde7a1 (57 Kda) Is Located Mostly To Soluble Cellular FractionsIsoform Pde7a2: CytoplasmPde7a2 (50 Kda) Is Located To Particulate Cellular Fractions |
| Alternative Antibody Names | Anti-High Affinity 3' -5'-Cyclic-Amp Phosphodiesterase 7a antibodyAnti-Hcp1 antibodyAnti-Tm22 antibodyAnti-Camp-Specific Phosphodiesterase 7a antibodyAnti-PDE7A antibody |
Information sourced from Uniprot.org
